From the east (center city Philadelphia and New Jersey):
Take 76 West to exit 340A to Lincoln Drive. Follow Lincoln Drive for 3.8 miles until it dead-ends, then turn right onto W Allens Lane. Go 0.4 miles to the dead-end and turn right onto Germantown Avenue. Go one block to the first light, then turn left onto E Mt Airy Avenue. The church will be on the right immediately after the animal hospital. Ample parking is available behind the church.

From the west:
Take 76 East to exit 340A to Lincoln drive, then as above.

From the south/southwest:
Take US 1/City Line Avenue/City Avenue North to Lincoln Drive, then as above.

Public transportation:
Holy Cross is within walking distance of the Sedgwick train station on the Chestnut Hill East Septa Line, Allen Lane Station on the Chestnut Hill West Line, and the Septa buses on Germantown Avenue (#23) and Mount Pleasant (H).